Stages 1 and 2 are the lighter stages of sleep, occurring just as a person begins to fall into sleep. Non-REM sleep makes up 75% of a normal sleep cycle and consists of stages 1-4, each typically lasting for 5-15 minutes. A normal sleep cycle will go through stages 1-4 before moving into REM, and then alternating between There are two main categories for these stages: REM (Rapid Eye Movement) sleep and non-REM sleep. In conclusion, short average duration of NREM/REM cycles, especially average REM sleep duration in each cycle, in cognitively normal elderly might be used as an early marker of cognitive decline.ĭementia mild cognitive impairment sequential hypothesis sleep.Healthy sleep cycles To fully understand how narcolepsy affects the brain, first you must learn a bit about how a normal brain works…Ī healthy person will get around 6-8 hours of sleep on average, and in this time they will go through several “stages” of sleep. When its substructure and NREM and REM sleep outside of cycles were considered simultaneously, the average REM sleep duration per cycle (OR, 0.87 p = 0.03) was significantly related to the outcome. A short average cycle length (OR, 0.97 p = 0.02) was significantly associated with cognitive decline. Of 235 participants (mean age 68 years 60% female) at baseline, 14 (5.9%) developed MCI/dementia at follow-up. After 4 years, the development of mild cognitive impairment (MCI) or dementia was related to the measures of sleep architecture, including NREM/REM cycle parameters by logistic regression analyses. A NREM/REM cycle is a sequence of NREM and REM sleep, uninterrupted by a waking period of >2 min. They were cognitively normal and underwent overnight polysomnography at baseline. Community-dwelling elderly people in Korea from the Korean Longitudinal Study on Cognitive Aging and Dementia were enrolled. We explored the association between NREM/REM cycle-related sleep architecture and cognitive decline. Prospective studies concerning sleep architecture and cognitive function have focused on individual sleep measures per se, without considering the complementary role of non-REM (NREM) and REM sleep. 18 National Institute of Dementia, Seongnam, Korea.17 Department of Brain and Cognitive Sciences, Seoul National University, College of Natural Sciences, Seoul, Korea.16 Department of Psychiatry, Kangwon National University, School of Medicine, Chuncheon, Korea.15 Department of Psychiatry, Dankook University Hospital, Cheonan, Korea.14 Department of Neuropsychiatry, Inje University Sanggye Paik Hospital, Seoul, Korea.13 Department of Psychiatry, Seoul National University, College of Medicine, Seoul, Korea.12 Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Korea.11 Department of Neuropsychiatry, Kyunggi Provincial Hospital for the Elderly, Yongin, Korea.
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